An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22
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An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22.
The control of human ribosomal protein L22 (rpL22) to enter into the nucleolus and its ability to be assembled into the ribosome is regulated by its sequence. The nuclear import of rpL22 depends on a classical nuclear localization signal of four lysines at positions 13-16. RpL22 normally enters the nucleolus via a compulsory sequence of KKYLKK (I-domain, positions 88-93). An acidic residue clus...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2000
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(00)02118-9